Targeted & controlled bone healing

Kuros’ Synthetic Cross-Linking Technology Platform

Kuros has a broad platform technology for developing biomaterials based on synthetic matrices. This technology is based on a highly specific cross-linking chemistry that can be carried out in situ after application on tissues in the body, without heat generation or significant biocompatibility concerns.  One significant advantage of this technology is that the characteristics of the synthetic matrices can be easily controlled through the molecular make-up of each individual component. As such, this technology provides a high degree of flexibility in engineering the products, allowing the specifications to precisely match the clinical needs. Product characteristics that can be controlled include degradability, strength, and injectability. By utilizing different molecules for the components of the matrices, the synthetic matrices can either be soft and elastic or have a compressive strength greater than bone, for example. Degradable matrices can be designed to degrade in vivo into safe by-products that can be easily cleared from the body.

Publications on Synthetic Cross-Linking Technologies

Wechsler S, Fehr D, Molenberg A, Raeber G, Schense JC, Weber FE.
A novel, tissue occlusive poly(ethylene glycol) hydrogel material.
J Biomed Mater Res A. 2008 May;85(2):285-92. Zisch AH, Lutolf MP, Ehrbar M, Raeber GP, Rizzi SC, Davies N, Schmokel H, Bezuidenhout D, Djonov V, Zilla P, Hubbell JA.
Cell-demanded release of VEGF from synthetic, biointeractive cell ingrowth matrices for vascularized tissue growth.
FASEB J. 2003 Dec;17(15):2260-2 Lutolf MP, Hubbell JA.
Synthesis and physicochemical characterization of end-linked poly (ethylene glycol)-co-peptide hydrogels formed by Michael-type addition.
Biomacromolecules. 2003 May-Jun;4(3):713-22. Lutolf MP, Weber FE, Schmoekel HG, Schense JC, Kohler T, Muller R, Hubbell JA.
Repair of bone defects using synthetic mimetics of collagenous extracellular matrices.
Nat Biotechnol. 2003 May;21(5):513-8. Lutolf MP, Lauer-Fields JL, Schmoekel HG, Metters AT, Weber FE, Fields GB, Hubbell JA.
Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: engineering cell-invasion characteristics.
Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5413-8. Vernon B, Tirelli N, Bachi T, Haldimann D, Hubbell JA.
Water-borne, in situ crosslinked biomaterials from phase-segregated precursors.
J Biomed Mater Res. 2003 Mar 1;64A(3):447-56. Elbert DL, Hubbell JA.
Conjugate addition reactions combined with free-radical cross-linking for the design of materials for tissue engineering.
Biomacromolecules. 2001 Summer;2(2):430-41. Lutolf MP, Tirelli N, Cerritelli S, Cavalli L, Hubbell JA.
Systematic modulation of Michael-type reactivity of thiols through the use of charged amino acids.
Bioconjug Chem. 2001 Nov-Dec;12(6):1051-6. Elbert DL, Pratt AB, Lutolf MP, Halstenberg S, Hubbell JA.
Protein delivery from materials formed by self-selective conjugate addition reactions.
J Control Release. 2001 Sep 11;76(1-2):11-25. Schense JC, Hubbell JA.
Three-dimensional migration of neurites is mediated by adhesion site density and affinity.
J Biol Chem. 2000 Mar 10;275(10):6813-8.
Kuros Biosciences AG
Wagistrasse 25, 8952 Schlieren, Switzerland
Tel: +41 44 733 47 47   Fax: +41 44 733 47 40   Email: info@kurosbio.com

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    KUR-113
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    KUR-113
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    Neuroseal (KUR-023)

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  4. Immune Modulation

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Synthetic Cross-Linking Technology

Kuros’ Synthetic Cross-Linking Technology Platform

Kuros has a broad platform technology for developing biomaterials based on synthetic matrices. This technology is based on a highly specific cross-linking chemistry that can be carried out in situ after application on tissues in the body, without heat generation or significant biocompatibility concerns.  One significant advantage of this technology is that the characteristics of the synthetic matrices can be easily controlled through the molecular make-up of each individual component. As such, this technology provides a high degree of flexibility in engineering the products, allowing the specifications to precisely match the clinical needs. Product characteristics that can be controlled include degradability, strength, and injectability. By utilizing different molecules for the components of the matrices, the synthetic matrices can either be soft and elastic or have a compressive strength greater than bone, for example. Degradable matrices can be designed to degrade in vivo into safe by-products that can be easily cleared from the body.

Publications on Synthetic Cross-Linking Technologies

Wechsler S, Fehr D, Molenberg A, Raeber G, Schense JC, Weber FE.
A novel, tissue occlusive poly(ethylene glycol) hydrogel material.
J Biomed Mater Res A. 2008 May;85(2):285-92. Zisch AH, Lutolf MP, Ehrbar M, Raeber GP, Rizzi SC, Davies N, Schmokel H, Bezuidenhout D, Djonov V, Zilla P, Hubbell JA.
Cell-demanded release of VEGF from synthetic, biointeractive cell ingrowth matrices for vascularized tissue growth.
FASEB J. 2003 Dec;17(15):2260-2 Lutolf MP, Hubbell JA.
Synthesis and physicochemical characterization of end-linked poly (ethylene glycol)-co-peptide hydrogels formed by Michael-type addition.
Biomacromolecules. 2003 May-Jun;4(3):713-22. Lutolf MP, Weber FE, Schmoekel HG, Schense JC, Kohler T, Muller R, Hubbell JA.
Repair of bone defects using synthetic mimetics of collagenous extracellular matrices.
Nat Biotechnol. 2003 May;21(5):513-8. Lutolf MP, Lauer-Fields JL, Schmoekel HG, Metters AT, Weber FE, Fields GB, Hubbell JA.
Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: engineering cell-invasion characteristics.
Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5413-8. Vernon B, Tirelli N, Bachi T, Haldimann D, Hubbell JA.
Water-borne, in situ crosslinked biomaterials from phase-segregated precursors.
J Biomed Mater Res. 2003 Mar 1;64A(3):447-56. Elbert DL, Hubbell JA.
Conjugate addition reactions combined with free-radical cross-linking for the design of materials for tissue engineering.
Biomacromolecules. 2001 Summer;2(2):430-41. Lutolf MP, Tirelli N, Cerritelli S, Cavalli L, Hubbell JA.
Systematic modulation of Michael-type reactivity of thiols through the use of charged amino acids.
Bioconjug Chem. 2001 Nov-Dec;12(6):1051-6. Elbert DL, Pratt AB, Lutolf MP, Halstenberg S, Hubbell JA.
Protein delivery from materials formed by self-selective conjugate addition reactions.
J Control Release. 2001 Sep 11;76(1-2):11-25. Schense JC, Hubbell JA.
Three-dimensional migration of neurites is mediated by adhesion site density and affinity.
J Biol Chem. 2000 Mar 10;275(10):6813-8.